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Contribution Oral

Budker INP - Conference Hall
SR for medicine and biology application

Nanoradiator therapy and synchrotron X-ray imaging of malignant brain tumor

Speakers

  • Prof. Jong-Ki KIM

Primary authors

Co-authors

Content

Glioblastoma malformation is typical intractable malignant brain tumor that has less than 2 years as mean survival due to infiltrative nature in conjunction with microvascular malformation (MVP). Conventional drug delivery is limited by intact BBB in normal tissue surrounding MVP, and current radiotherapy is not indicative due to infiltration of tumor cell into normal brain. Therefore, tumor-infiltrating MVP should be therapeutic target. Recently we imaged MVP with tumor infiltration in rat glioma model using synchrotron X-ray DEI CT technique. High-Z nanoparticles play a role as nanoradiator, burst release of low energy electrons and characteristic X-ray fluorescence, when subject to X-ray photoelectric ionization or high-energy ion beam-irradiated Coulomb scattering. During last decade we have developed dosimetry of nanoradiator effect and medical application of novel site-specific nanoradiator therapy using either monochromatic synchrotron X-ray or traversing Bragg-peak proton beam. Eventually nanoradiator therapy provide a new platform of therapeutic nanobeacon technology by converting prodrug inert gold/iron nanoparticle into electron-emitting drug. Realization of this concept in oncology and non-oncology would be demonstrated in this presentation. In addition, high-resolution X-ray diffraction CT imaging of skull-based brain is challenging and discussed with our resolving efforts