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SUMMARY:SRXRF STUDY OF CHEMICAL ELEMENTS CONTENT IN  THE ATHEROSCLEROTIC P
 LAQUE OF HEART VESSELS
DTSTART;VALUE=DATE-TIME:20160705T090000Z
DTEND;VALUE=DATE-TIME:20160705T100000Z
DTSTAMP;VALUE=DATE-TIME:20260719T182743Z
UID:indico-contribution-1188@indico.inp.nsk.su
DESCRIPTION:Speakers: Emiliya Zhuravskaya (Institute of Internal and Preve
 ntive Medicine\, Siberian Branch of the Russian Academy of Medical Science
 s)\nThe main problem of cardiology\, that society faces\, is the acute hea
 rt failure (AHF). Many factors have effect on the development of cardiovas
 cular diseases. The primary reasons of myocardial infarction and stroke ar
 e hypertension and sclerosis that lead\, with time\, to calcification and 
 contraction of arteries which prevents blood to enter heart and brain. In 
 heart vessels an atherosclerotic plaque forms which closing a vascular lum
 en\, causes IDH\, and myocardial infarction. Therefore\, studying the deep
  mechanisms of plaque formation is the focus of attention. The atheroscler
 otic processes in heart vessels may be explained by several theories that 
 account for the complex processes of atherogenesis. Many papers are devote
 d to the cellular composition of plaques. Little\, however\, is known abou
 t the element composition of the atherosclerotic nidus of coronary vessels
 . Elucidating the content and ratio of chemical elements upon plaque forma
 tion in heart vessels may substantially supplement the missing stages of t
 his process.\nThe goal of this study is to determine and estimate a comple
 x of chemical elements in the substrates of the atherosclerotic nidus of h
 uman heart vessels.\nThe method of X-ray fluorescence analysis with synchr
 otron radiation (SRXRF) (VEPP-3\, store ring) was used in Center "Siberian
  Synchrotron and Terahertz Radiation Center (SSTRC)" to study the content 
 of chemical elements in vascular walls and in atherosclerotic plaques (sta
 ble and unstable) drawn from men after operative therapy. As the amount of
  material for studying is limited\, we have developed a special technique 
 for preparing the samples of vascular and plaque tissues.\nWe measured the
  concentrations of K\, Ca\, Cr\, Mn\, Fe\, Co\, Ni\, Cu\, Zn\, Br\, Sr\, Z
 r\, and Pb. A comparison was made of the content of elements in the tissue
 s of heart vessels with atherosclerotic plaques and of the element composi
 tions of stable and unstable plaques. In all the samples studied\, prevail
 ing is Ca\, particularly in instable plaques. The concentrations of K\, Ca
 \, Cr\, Mn\,Fe\, Ni\, Zn and Br in atherosclerotic plaques are much higher
  than in the vascular tissues of heart. At the background of predominant C
 a no reliable difference has been revealed in the elements measured in sta
 ble and unstable plaques. A high association of Ca with Fe\, Zn\, and Sr h
 as been recorded in the atherosclerotic plaques.\nThus\, the SRXRF method 
 has first allowed one to determine the multielement composition in the sub
 strates of the atherosclerotic nidus of human heart vessels.\n\nhttps://in
 dico.inp.nsk.su/event/3/contributions/1188/
LOCATION:Budker INP 2nd and 3rd floors
URL:https://indico.inp.nsk.su/event/3/contributions/1188/
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