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SUMMARY:Investigation of the principles of detection of small amounts of n
 anoparticles of drugs and their conglomerates during the synthesis and tra
 nsport in vivo using methods of X-ray synchrotron radiation
DTSTART;VALUE=DATE-TIME:20160705T054000Z
DTEND;VALUE=DATE-TIME:20160705T060000Z
DTSTAMP;VALUE=DATE-TIME:20260419T060651Z
UID:indico-contribution-1250@indico.inp.nsk.su
DESCRIPTION:Speakers: Alexey Ancharov (Institute of Solid State Chemistry 
 and Mechanochemistry SB RAS)\nThe basic idea of the investigation is using
  the unique properties of the synchrotron radiation can receive informatio
 n about the drug are in the gastrointestinal tract (GIT) of a living body 
 at low concentrations. In particular: the phase state\, i.e\, tablet disso
 lved in the stomach or not\; the charge state\, i.e\, the drug is active o
 r passive\; of the time (and place) of sedimentation of the drug\; about t
 he localization of the drug on the damaged wall of the digestive tract.\nI
 n this project\, the first steps was made towards the realization of the i
 dea with using a model system. The experiment was conducted at the experim
 ental station of synchrotron radiation (SR) №4 VEPP -3. Medicament (in o
 ne experiment in the crystal\, and in the other - in liquid form) was pour
 ed into the stomach of a turkey\, and irradiated with a narrow beam with a
 n energy 33.7 keV. With area detector mar-350 diffraction pattern of the d
 rug was reseved\, imposed on the scattering from the tissue of the stomach
 . The main objective was to allocate the sum of the diffraction pattern in
 formation about the structure of the drug. The main result of the experime
 nt - using SR can receive information about the crystal lattice of drugs i
 n real biological.\nThus\, using the an unique properties of synchrotron r
 adiation in this study managed to obtain structural information about drag
 \, are in conditions close to real ones (in terms of interaction with X-ra
 ys) - virtually the same as in the stomach of a living organism. The drug 
 was in solid or in dissolved form.\nAs an object of research we selected a
 nti-ulcer drug substance based on bismuth tripotassium dicitrate (BTD). BT
 D is a drug with bactericidal activity against Helicobacter pylori has ant
 i-inflammatory and astringent. Work was carried out on behalf of the Minis
 try of Health RF for the development of domestic analogue drugs De Nol (Ne
 therlands).\nThe project succeeded in synthesizing a complete analogue of 
 imported medicines De-Nol (Netherlands) and to explore its metabolism in t
 he chemical environment similar to the environment in different parts of t
 he gastrointestinal tract.\nBy simulating the behavior of BTD in the gastr
 ointestinal tract by small-angle x-ray scattering discovered that bismuth 
 forms a stable complex of a colloidal particle. The particle has size in o
 rder of 22 A. If the solution is diluted with water particle size changes.
 \nThe structure of the colloidal particles was investigated by X-ray diffr
 action on a synchrotron radiation beam. It was found that the structure is
  sensitive to pH\n\nhttps://indico.inp.nsk.su/event/3/contributions/1250/
LOCATION:Budker INP Conference Hall
URL:https://indico.inp.nsk.su/event/3/contributions/1250/
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