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SUMMARY:X-ray Dark-Field Imaging (XDFI): Recent Developments and Clinical 
 Applications
DTSTART;VALUE=DATE-TIME:20160705T024000Z
DTEND;VALUE=DATE-TIME:20160705T032000Z
DTSTAMP;VALUE=DATE-TIME:20260411T140749Z
UID:indico-contribution-1251@indico.inp.nsk.su
DESCRIPTION:Speakers: Masami ANDO (Tokyo University of Science)\nThis pape
 r describes a novel x-ray phase contrast imaging technique called X-ray da
 rk-field imaging (XDFI) that has been under development for the past 10 ye
 ars. We describe the theory behind XDFI\, the x-ray optics required for im
 plementing it in practice\, and algorithms used for 2D\, 2.5D\, and 3D ima
 ge reconstruction. The XDFI optical chain consists of an asymmetrically cu
 t\, Bragg-type monochromator-collimator that provides a planar monochromat
 ic x-ray beam\, a positioning stage for the specimens\, a Laue-case angle 
 analyzer\, and one or two cameras to capture the dark and bright field ima
 ges. We demonstrate soft-tissue discrimination capabilities of XDFI by rec
 onstructing images with absorption and phase contrast. By using a variety 
 of specimens such as breast tissue with cancer\, joints with articular car
 tilage\, ex-vivo human eye specimen\, and others\, we show that refraction
 -based contrast derived from XDFI is more effective in characterizing norm
 al anatomy\, articular pathology\, and neoplastic disease than the convect
 ional absorption-based images. For example\, XDFI of breast tissue can dis
 criminate between the normal and diseased terminal duct lobular unit\, and
  between invasive and in-situ cancer. The final section of this paper is d
 evoted to potential future developments to enable clinical and histo-patho
 logical applications of this technique. \n\nReferences\n\n[1] Simple x ray
  dark- and bright- field imaging using achromatic Laue optics\, M. Ando\, 
 A. Maksimenko\, H. Sugiyama\, W. Pattanasiriwisawa\, K. Hyodo and C. Uyama
 \, Jpn. J. Appl. Phys. 41\, L1016 (2002). \n\n[2] Computed tomographic rec
 onstruction based on x-ray refraction contrast\, A. Maksimenko\, M. Ando\,
  H. Sugiyama\, T. Yuasa\, Appl. Phys. Lett. 86 124105-1 (2005). \n\n[3] X-
 ray refraction-contrast computed tomography images using dark-field imagin
 g optics\, N. Sunaguchi\, T. Yuasa\, Q. Huo\, S. Ichihara and M. Ando\, Ap
 pl. Phys. Letters 97\,153701-1 (2010).\n\n[4] Iterative reconstruction alg
 orithm for analyzer-based phase-contrast CT of hard and soft tissue\, N. S
 unaguchi\, T.Yuasa\, M. Ando\, Appl. Phys. Letters 103\, 143702-1 (2013). 
    \n\n[5] 3-D reconstruction and virtual ductoscopy of high-grade ductal 
 carcinoma in situ of the breast with casting type calcifications using ref
 raction-based x-ray CT\, S. Ichihara\, M. Ando\, A. Maksimenko\, T. Yuasa\
 , H. Sugiyama\, E. Hashimoto\, K. Yamasaki\, K. Mori\, Y. Arai and T. Endo
 \, Virchows Archiv 451\, 41 (2008).\n\n[6] X-ray phase contrast imaging in
  the dark field: implementation and evaluation using excised tissue specim
 ens\, M. Ando\, N. Sunaguchi\, Y. Wu\, S. Do\, Y. Sung\, A. Louissaint\, T
 . Yuasa\, S. Ichihara\, R. Gupta\, Eur. Rad. 23\, 3021 (2013).　\n\n[7] X
 -ray Dark-Field Imaging (XDFI): Recent Developments and Clinical Applicati
 ons\, M. Ando\, N. Sunaguchi\, D. Shimao\, A. Pan\, T. Yuasa\, K. Mori\, Y
 . Suzuki\, G. Jin\, J.-K. Kim\, Jae-Hong Lim\, S.-J. Seo\, S. Ichihara\, N
 . Ohura\, R. Gupta\, submitted to Eur. J. Med. Phys.\n\nhttps://indico.inp
 .nsk.su/event/3/contributions/1251/
LOCATION:Budker INP Conference Hall
URL:https://indico.inp.nsk.su/event/3/contributions/1251/
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