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SUMMARY:Nanoradiator therapy and synchrotron X-ray imaging of malignant br
 ain tumor
DTSTART;VALUE=DATE-TIME:20160705T052000Z
DTEND;VALUE=DATE-TIME:20160705T054000Z
DTSTAMP;VALUE=DATE-TIME:20260811T204508Z
UID:indico-contribution-1293@indico.inp.nsk.su
DESCRIPTION:Speakers: Jong-Ki Kim (Catholic University of Daegu\, School o
 f Medicine)\nGlioblastoma malformation is typical intractable malignant br
 ain tumor that has less than 2 years as mean survival due to infiltrative 
 nature in conjunction with microvascular malformation (MVP).  Conventional
  drug delivery is limited by intact BBB in normal tissue surrounding MVP\,
  and current radiotherapy is not indicative due to infiltration of tumor c
 ell into normal brain. Therefore\, tumor-infiltrating MVP should be therap
 eutic target. Recently we imaged MVP with tumor infiltration in rat glioma
  model using synchrotron X-ray DEI CT technique. High-Z nanoparticles play
  a role as nanoradiator\, burst release of low energy electrons and charac
 teristic X-ray fluorescence\, when subject to X-ray photoelectric ionizati
 on or high-energy ion beam-irradiated Coulomb scattering. During last deca
 de we have developed dosimetry of nanoradiator effect and medical applicat
 ion of novel site-specific nanoradiator therapy using either monochromatic
  synchrotron X-ray or traversing Bragg-peak proton beam. Eventually nanora
 diator therapy provide a new platform of therapeutic nanobeacon technology
  by converting prodrug inert gold/iron nanoparticle into electron-emitting
  drug. Realization of this concept in oncology and non-oncology would be d
 emonstrated in this presentation. In addition\, high-resolution X-ray diff
 raction CT imaging of skull-based brain is challenging and discussed with 
 our resolving efforts\n\nhttps://indico.inp.nsk.su/event/3/contributions/1
 293/
LOCATION:Budker INP Conference Hall
URL:https://indico.inp.nsk.su/event/3/contributions/1293/
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