Dr
Alexander Zaboronok
(University of Tsukuba)
The main treatment effect of boron neutron capture therapy (BNCT) depends on the release of alpha-particles inside tumor cells, and direct measurement of the absorbed dose becomes impossible. To solve the problem of absorbed dose evaluation, measurement of gamma-rays produced by golden foils that are placed close to the irradiated samples and activated by neutrons is typically used....
Mr
Dmitry Gruzdev
(Postovsky Institute of Organic Synthesis of the Russian Academy of Sciences (Ural Branch))
1,2-Dicarba-closo-dodecaborane and 7,8-dicarba-nido-undecaborane (closo- and nido-carboranes) derivatives characterizing by a high boron content are of significant interest as chemical agents for BNCT. Amino acids are natural metabolites that can be selectively absorbed by tumor cells. Preparation of carborane-containing amino acid derivatives represents a promising approach to the development...
Mrs
Anna Kasatova
(Novosibirsk State University)
, Mr
Nikita Filin
(Novosibirsk State University)
, Mr
Roman Sibirtsev
(Novosibirsk State University)
Boron neutron capture therapy is a treatment for malignant tumors, both primary and recurrent. Most clinical trials have been conducted in patients with glioblastoma, which are aggressive and resistant to standard treatment of brain tumors. For the best implementation of the method of boron neutron capture therapy, targeted delivery agents, containing a sufficient number of boron-10 atoms are...
Mrs
Tatyana Avramchuk
(Institute of Chemical Biology and Fundamental Medicine)
Development of boron nanocarriers as theranostic agents for boron neutron capture therapy has received extensive attention in recent years. Different albumin conjugates have proved over the years to be highly biocompatible, with some of them being FDA approved and currently used in clinical treatments. However, the chemistry for site-directed introduced boron into human serum albumin is quite...
Mr
Ilia Urupa
(National Research Nuclear University MEPhI (Moscow Engineering Physics Institute))
In this work, we calculated the parameters of the biological protection of the neutron generator NG-24 manufactured by FSUE VNIIA in order to ensure the radiation safety of medical personnel. The calculation was carried out using the Geant4 software package. Calculations were performed for materials such as polyethylene and boron polyethylene. Capacities of equivalent doses of neutron and...
Mrs
Anna Druzina
(A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS))
Boron neutron capture therapy (BNCT) is a binary method for the treatment of cancer. Last years various tumor-targeting boron nanocarriers, including liposomes, have been intensively studied as potential candidates for a boron delivery system [1]. Liposomes composed of natural lipids are biodegradable and biologically inert and possess limited intrinsic toxicity. They tend to accumulate in...
Dr
Darya Novopashina
(Institute Chemical Biology and Fundamental Medicine)
Boron neutron capture therapy (BNCT) is a promising therapeutic approach for the treatment of malignant tumors. Polyhedral boranes, such as boron clusters, attract considerable attention because they combine high boron content with relative metabolic inertness and low toxicity. Introduction of boron clusters to the oligonucleotide constructions permits to create agents for BNCT which can...
Mr
Vladimir Kanygin
(Novosibirsk State University)
Actual problems of BNCT are the insufficient selectivity of boron delivery agents available at the disposal, the absence of a single protocol for the treatment of patients, the complexity of the use of nuclear reactors in clinical practice and the associated limitations in the use of the method. These problems can be solved by using compact accelerators as neutron sources, with the possibility...
Prof.
Vladimir Silnikov
(Institute of Chemical Biology and Fundamental Medicine, SB RAS)
As the most abundant protein with a variety of physiological functions, albumin has been used extensively for the delivery of therapeutic molecules. Our work focuses on optimizing the bioavailability of a probe by exploiting the inherent circulatory transport mechanisms of albumin. Herein, human serum albumin has been functionalized with a combination of maleimide of a fluorescent dye Cy7 and...
Mr
Rinat Mukhamadiyarov
(Municipal Budgetary Healthcare Institution Kemerovo Cardiology Dispensary, 6, Sosnoviy blvd, Kemerovo, 650002, Russia)
Для реализации борнейтронзахватной терапии (БНЗТ) необходимы с одной стороны высокая концентрации В-10 в тканях опухоли, с другой создание – достаточный градиент концентрации по этому элементу между опухолью и здоровыми тканями. Величина этого градиента должна быть равной или выше трехкратного.
В настоящее время для БНЗТ широко применяют обогащённые препараты борфенилаланин (BPA) и...
