Speaker
Mr
Alexey Ancharov
(Institute of Solid State Chemistry and Mechanochemistry SB RAS)
Description
The basic idea of the investigation is using the unique properties of the synchrotron radiation can receive information about the drug are in the gastrointestinal tract (GIT) of a living body at low concentrations. In particular: the phase state, i.e, tablet dissolved in the stomach or not; the charge state, i.e, the drug is active or passive; of the time (and place) of sedimentation of the drug; about the localization of the drug on the damaged wall of the digestive tract.
In this project, the first steps was made towards the realization of the idea with using a model system. The experiment was conducted at the experimental station of synchrotron radiation (SR) №4 VEPP -3. Medicament (in one experiment in the crystal, and in the other - in liquid form) was poured into the stomach of a turkey, and irradiated with a narrow beam with an energy 33.7 keV. With area detector mar-350 diffraction pattern of the drug was reseved, imposed on the scattering from the tissue of the stomach. The main objective was to allocate the sum of the diffraction pattern information about the structure of the drug. The main result of the experiment - using SR can receive information about the crystal lattice of drugs in real biological.
Thus, using the an unique properties of synchrotron radiation in this study managed to obtain structural information about drag, are in conditions close to real ones (in terms of interaction with X-rays) - virtually the same as in the stomach of a living organism. The drug was in solid or in dissolved form.
As an object of research we selected anti-ulcer drug substance based on bismuth tripotassium dicitrate (BTD). BTD is a drug with bactericidal activity against Helicobacter pylori has anti-inflammatory and astringent. Work was carried out on behalf of the Ministry of Health RF for the development of domestic analogue drugs De Nol (Netherlands).
The project succeeded in synthesizing a complete analogue of imported medicines De-Nol (Netherlands) and to explore its metabolism in the chemical environment similar to the environment in different parts of the gastrointestinal tract.
By simulating the behavior of BTD in the gastrointestinal tract by small-angle x-ray scattering discovered that bismuth forms a stable complex of a colloidal particle. The particle has size in order of 22 A. If the solution is diluted with water particle size changes.
The structure of the colloidal particles was investigated by X-ray diffraction on a synchrotron radiation beam. It was found that the structure is sensitive to pH
Primary author
Mr
Alexey Ancharov
(Institute of Solid State Chemistry and Mechanochemistry SB RAS)
Co-authors
Prof.
Boris Tolochko
(Institute of solid state chemistry and mechanochemistry)
Ms
Ekaterina Naydenko
(Institute of Solid State Chemistry and Mechanochemistry SB RAS)
Dr
Konstantin Kuper
(Budker Institute of Nuclear Physics)
Mr
Marat Sharafutdinov
(ISSCM SB RAS, BINP SB RAS)
Mr
Mikhail Mikhailenko
(Institute of Solid State Chemistry and Mechanochemistry SB RAS)
Mr
uriy Yukhin
(Institute of Solid State Chemistry and Mechanochemistry SB RAS)
