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Contribution Oral

SR for medicine and biology application

Application of X-ray microtomography to the investigation of gallbladder stones



Primary authors

  • Mr. Yuri KRIVONOSOV (Shubnikov Institute of Crystallography, FSRC "Crystallography and photonics" RAS, Moscow, Russian Federation)



Cholelithiasis is characterized by the appearance and growth of stones in the gallbladder. Nowadays gallbladder disease comes to the first place among pathology of a digestive tract. It tends to grow steadily and is to be relevant in gastroenterology. Despite the fact that there are many attempts to use computed tomography techniques for the practical diagnosis of gallbladder stones, the problem of diagnosis of cholesterol cholelithiasis from its other forms remains unresolved. In this work we have investigated the set of gallbladder stones. The experimental setup for microtomography with conventional X-ray source was developed in FSRC “Crystallography and Photonics” RAS, Moscow. The measurements were performed at the energy of X-radiation 17.5 keV. Our approach to analysis of experimental data as well as the reconstruction algorithm for X-ray tomography measurements was described in [1]. The X-ray microtomograms of gallbladder stones in the amount of 23 pieces were measured and 3D-distribution of the linear absorption coefficients was calculated by algebraic retrieval algorithm. A good agreement between values of linear absorption coefficients obtained from X-ray tomography experiments and theoretical calculations for cholesterol type gallbladder stones is demonstrated. The possibility of using the X-ray tomography method to diagnostic of gallbladder stones at the range of probe radiation from 50 to 100 keV is discussed.

This work was supported by the Federal Agency of Scientific Organizations (Agreement No 007-ГЗ/Ч3363/26) in part of tomography experiments.

[1]. V.E.Prun, D.P.Nikolaev, A.V.Buzmakov, M.V.Chukalina, V.E.Asadchikov. Effective regularized algebraic reconstruction technique for computed tomography. Crystallography Reports December 2013, Volume 58, Issue 7, pp 1063-1066.